how is crohn’s disease diagnosed

Diagnosing Crohn’s disease requires a multi-layered approach combining blood work, stool analysis, endoscopic imaging, and tissue biopsy. According to 2025 ACG guidelines, fecal calprotectin testing now serves as a frontline screening tool before invasive procedures. Most patients undergo colonoscopy with biopsy to confirm inflammation patterns, though newer biomarker panels and imaging technologies are reducing diagnostic